Pioneering innovations in early life nutrition for GI health

Human milk is an important source of beneficial bacteria that may help to colonise the infant GI tract, contributing to the composition of the gut microbiota.¹Wopereis H del. et al. Pediatr Allergy Immuno. Published on 2014;25:428-38 ,²Abrahamse E, et al. Food Dig. Published on 2012;3:63-77 ,³Scholtens PA, et al. Ann Rev Food Sci Technol. Published on 2012;3:425-47 In addition, human milk is a rich source of oligosaccharides, which exert a prebiotic effect on the infant gut, supporting the growth of beneficial bacteria such as bifidobacteria and lactobacilli.⁴Jeurink PV, et al. Benef Microbes. Published on 2013;4:17-30 These beneficial bacteria utilise human milk oligosaccharides as an energy source to produce short-chain fatty acids (SCFAs), which support gut maturation by stimulating growth and differentiation of the gut mucosa.⁵Oozeer R, et al. Br J Nutr. Published on 2010;103:1539-44

 scGOS/lcFOS (9:1)

Inspired by human milk, we were the first to include prebiotic oligosaccharides in our infant formulas. Our unique, patented blend of short chain galacto-oligosaccharides (scGOS) and long chain fructo-oligosaccharides (lcFOS), in a 9:1 ratio, was first introduced into our infant formulas in 2000. The health benefits of scGOS/lcFOS (9:1) are validated by almost 20 years of research, with a total of over 30 studies, described in >55 scientific publications. These health benefits include:

• increased beneficial gut microbiota, closer to breastfed infants⁷Moro, et al. J Pediatr Gastroenterol Nutr. Published on 2002; 34:291- 5 ,⁸Boehm del. et al. Arch Dis Child. Published on 2002; 86: F178-81 ,⁹Knol, et al. J Pediatr Gastroenterol Nutr. Published on 2005a; 40:36-42 ,¹⁰Haarman, et al. Appl Environ Microbiol. Published on 2005; 71:2318-24 ,¹¹Knol, et al. J Pediatr Gastroenterol Nutr. Published on 2002; 34:291-5 ,¹²Descim et al. Orv Hetil. Published on 2005; 146:2445-50
• stool patterns closer to that of breastfed infants¹³Knol, et al. J Pediatr Gastroenterol Nutr. Published on 2005a; 40:36-42
• reduction in the incidence of gastroenteritis, eczema and allergy ¹⁴Boehm, et al. Arch Dis Child. Published on 2002; 86: F178-81 ,¹⁵Bruzzese, et al. Clin Nutr . Published on 2009;28:156-61 ,¹⁶Arslanoglu, et al. J Nutr. Published on 2007; 137:2420-24 ,¹⁷Arslanoglu, et al. J Nutr. Published on 2008; 138:1091-95 ,¹⁸Arslanoglu, et al. J Biol Regul Homeost Agents . Published on 2012;26:59

Lactofidus^TM

We were also the first to develop a fermented infant formula, derived from our unique fermentation process, Lactofidus™. Involving two specific lactic acid-producing bacteria, this process results in a product containing microbial enzymes, bacterial metabolites (e.g. lactic acid), and bacterial cells and components. The formula based on Lactofidus™ fermentation process has been shown to reduce the frequency and intensity of intestinal gas in infants, which in turn reduces bloating and GI discomfort.¹⁹Roy, et al. Arch Pediatr. Published on 2004;11: 1546-54

Partly fermented formula with prebiotic mixture scGOS/lcFOS (9:1)

Now, our dedication has led us to design the next generation of infant nutrition, bringing together our two pioneering innovations. It is the first and only infant formula with a unique combination of fermented formula (from the Lactofidus™ process) and the prebiotic mixture scGOS/lcFOS (9:1). This innovative formula was found to be safe and well-tolerated in infants, enabling normal growth.²⁰Huet, et al. J Pediatr Gastroenterol Nutr . Published on 2016; 63:e43-53 Importantly, it has also been clinically proven to lower the incidence of colic²¹Vandenplasm et al. Eur J Pediatr. Published on 2016;321 doi 10.1007/s00431-016-2785-8 and has a stool softening effect to bring the stool pattern closer to that of breastfed infants.²²Herrera, et al. J Pediatr Gastroenterol Nutr. Published on 2015; 61:516-7 ,²³Vandenplas, et al. Arch Dis Child. Published on 2014;99:A91-92