Recently, A Dutch study group revealed the outcome of the INCA study. The investigators showed that 7 days of antibiotic treatment in the first week of life is associated with an increased risk for wheezing and infantile colics.
Further optimisation of the indications for starting antibiotics, early discontinuation if possible, or interventions with pre- or probiotics might limit these negative effects.
This prospective observational birth cohort study included 436 term infants, which were followed-up of one year. Of these infants, 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), versus a healthy untreated control group (N=285) (AB-).
This cohort will be followed the coming period. An abstract with additional data has been accepted by ESPGHAN as poster at the 51st annual meeting in Geneva, May 9-12 2018.
Read full publication here 1Oosterloo BC, van Elburg RM, Rutten NB, et al. Wheezing and infantile colic are associated with neonatal antibiotic treatment. P. Published on 2018;29(2):151-158. doi https://doi.org/10.1111/pai.12857
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| 1 | Oosterloo BC, van Elburg RM, Rutten NB, et al. Wheezing and infantile colic are associated with neonatal antibiotic treatment. P. Published on 2018;29(2):151-158. doi https://doi.org/10.1111/pai.12857 |
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