Title: Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated.
| Authors: | Huet F, Abrahamse-Berkeveld M, Tims S, Simeoni U, Beley G, Savagner C, Vandenplas Y, Hourihane JO |
| Published: | 2016 |
| Journal: | Journal of Pediatric Gastroenterology and Nutrition |
Historically, fermented formulae are used to promote digestibility and tolerance and are considered safe for use in infants (with respect to growth). Infant formulae containing the specific prebiotic mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/ lcFOS; 9:1) closer mimics human milk gut microbiota and stool characteristics, have a beneficial effect on immune function and are considered safe for use in infants.
Fermented formulae and a specific mixture of 90% short chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS in healthy term infants.
The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants. Irrespective of presence or dosage of fermented formula, beneficial effect of scGOS/lcFOS (9:1) on gut microbiota and stool characteristics was confirmed, indicated by the lower pH, lower Clostridium difficile levels, and higher secretory immunoglobulin A levels.