Title: Gut Microbiota Composition of Non-IgE Mediated Cow’s Milk Allergic Infants before and after Dietary Management with a Synbiotics-Supplemented Amino Acid-Based Formula
| Authors: | Harm Wopereis, Marleen Van Ampting, David C.A. Candy, Diego Peroni, Yvan Vandenplas, Adam Fox, Manon M. Oude Nijhuis, Lucien Harthoorn |
| Published: | 2017 |
| Journal: | Journal of Allergy and Clinical Immunology |
The objective of this prospective, randomised, double-blind controlled study was to investigate the gut microbiota composition of infants with non-IgE mediated cows’ milk allergy (CMA) receiving an amino acid-based formula (AAF) with synbiotics. Synbiotic (pre-and probiotic mixture) ingredients have indeed been suggested to improve early life microbiota development in CMA infants. Results showed that at 8 weeks, the proportions of bifidobacteria were significantly higher in the test group vs the control group, with levels close to the reference group (healthy breastfed infants). These results indicate that the AAF with specific synbiotics modulates the gut microbiota composition of non-IgE mediated CMA infants closer that of healthy infants.